Infertility is a problem affecting 10-15% of couples with a child wish. For about half of these couples, a male factor is (co-)responsible . Although for a lot of patients the origin of the problems can be detected, still approximately 30% remains undiagnosed. Two main categories of disorders can be distinguished: acquired and congenital. The last category can either be of genetic origin or can be due to a developmental disorder.
Our team is especially interested in men with a genetic cause of male infertility. For infertile men for whom sperm cells can be retrieved either from the ejaculate or by testicular sperm extraction, in vitro fertilization, possibly with intracytoplasmic sperm injection (ICSI) might be a solution for their fertility problems. As a consequence, also potential genetic causes of infertility can be transmitted. Therefore, it is important to identify and study these genetic causes in order to be able to adequately counsel the couples.
The general aims of our studies are:
Back to top
- To detect changes in the genome that are related to male infertility.
- To get more insight into the underlying mechanism and consequences of known causes of male infertility.
- To study genes expressed in testicular tissues, and therefore potentially involved in spermatogenesis.