Mieke Geens Team

Differentiation potential and malignancy of human pluripotent stem cells

CV Mieke Geens

Academic career

Since March 2013. RESEARCH PROFESSOR (10%), Research Group Reproduction and Genetics, VUB.

Since May 2010. POSTDOCTORAL RESEARCHER, Research Group Reproduction and Genetics, VUB.

October 2005 - May 2010. PhD STUDENT IN MEDICAL SCIENCES, Research Group Biology of the Testis, Vrije Universiteit Brussel (VUB, Belgium). Thesis: Strategies for fertility preservation and restoration in the male. Promotors: Prof. Dr. Herman Tournaye, Prof. Dr. Hilde Van de Velde.

September 2004 - June 2005. MASTERS DEGREE IN BIOMEDICAL SCIENCES. Vrije Universiteit Brussel (VUB, Belgium). Thesis: Transplantation of cryopreserved spermatogonial stem cells. Promotor: Prof. H. Tournaye, Vrije Universiteit Brussel (VUB, Belgium).

Teaching activities at the VUB

Since 2014. TOPICS IN BIOMEDICAL RESEARCH. First year master Biomedical Sciences.

2014-2015. BIOMEDICAL GENETICS, practicals. Third year bachelor Biomedical Sciences.

Since 2012. CONCEPTION AND DEFENSE OF A SCIENTIFIC HYPOTHESIS. Third year bachelor Biomedical Sciences and Medicine.

Since 2011. SHORT INTERNSHIP. First year master Biomedical Sciences.

Since 2011. MASTER THESIS BIOMEDICAL SCIENCES

Since 2012. MASTER THESIS BIOLOGY

Since 2014. MASTER THESIS INTERUNIVERSITARY PROGRAMME FOR MOLECULAR BIOLOGY.

PhD students

Maria Krivega. Public defence: 3 September 2015. PhD dissertation: Balancing between totipotency and differentiation in human embryos.

Christina Markouli. Since September 2013. PhD project: Effect of chromosomal abnormalities on the differentiation potential and malignant characteristics of human embryonic stem cells

Dominika Dziedzicka. Since September 2013. PhD project: Identification of molecular regulators of differentiation potential in human embryonic stem cells.

Alex Keller. Since September 2015. PhD project: Quantification and risk assessment of residual undifferentiated stem cells.

Institutional responsabilities at the VUB

Since 2013. Exchange coordinator for bachelor and master Biomedical Sciences and PhDs in Medical Sciences.

Since 2013. Member of the Educational Council for Biomedical Sciences

Since 2013. Member of the Facultary Commission International Relations (FACIR)

Since 2013. Member of the Council for International Policy (RIB) and the Office of the Council for International Policy

2011-2014. Elected member of the Board of the Faculty of Medicine and Pharmacy

Participation in scientific societies and journals

Co-founder of the BELGIAN SOCIETY FOR STEM CELL RESEARCH BeSSCR.

Junior deputy of the Special Interest Group 'Stem Cells' of the a href="https://www.eshre.eu">European Society for Human Reproduction and Embryology

Peer-reviewed publications

Krivega MV, Geens M, Heindryckx B, Santos-Ribeiro S, Tournaye H, Van de Velde H. Cyclin E1 plays a key role in balancing between totipotency and differentiation in human embryonic cells. Mol Hum Reprod, 2015, in press.

de la Kethulle de Ryhove L, Ansseau E, Nachtegael C, Pieters K, Vanderplanck C, Geens M, Sermon K, Wilton SD, Coppee F, Lagneaux L, Belayew A. The Role of D4Z4-Encoded Proteins in the Osteogenic Differentiation of Mesenchymal Stromal Cells Isolated from Bone Marrow. Stem Cells Dev, 2015, in press.

Welling M, Chen HH, Munoz J, Musheev MU, Kester L, Junker JP, Mischerikow N, Arbab M, Kuijk E, Silberstein L, Kharchenko PV, Geens M, Niehrs C, van de Velde H, van Oudenaarden A, Heck AJ, Geijsen N. DAZL regulates Tet1 translation in murine embryonic stem cells. EMBO Rep, 2015, 16:791-802.

Krivega MV, Geens M, Van de Velde H. CAR expression in human embryos and hESC illustrates its role in pluripotency and tight junctions. Reproduction, 2014, 148:531-544.

Nguyen HT, Markouli C, Geens M, Barbe L, Sermon K, Spits C. Human embryonic stem cells show low-grade microsatellite instability. Molecular Human Reproduction, 2014, 20:981-989.

Jacobs K, Mertzanidou A, Geens M, Thi Nguyen H, Staessen C, Spits C. Low-grade chromosomal mosaicism in human somatic and embryonic stem cell populations. Nat Communications, 2014, 5:4227.

De Paepe C, Krivega M, Cauffman G, Geens M, Van de Velde H. Totipotency and lineage segregation in the human embryo. Molecular Human Reproduction, 2014, 20:599-618.

Nguyen H, Geens M, Mertzanidou A, Jacobs K, Spits C. Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL. Molecular Human Reproduction, 2014, 20:168-77.

Sui L, Mfopou JK, Geens M, Sermon K, Bouwens L. Role of BMP4 signaling in pancreatic progenitor differentiation from human embryonic stem cells. Stem Cell Reviews and Reports, 2013, 9:569-77.

Nguyen H*, Geens M*, Spits C* (*all authors equally contributed to this work). Genetic and epigenetic instability in human pluripotent stem cells. Human Reproduction Update, 2013, 19:187-205.

Van Haute L, Spits C, Seneca S, Geens M, Sermon K. Human embryonic stem cells commonly display large mitochondrial DNA deletions. Nature Biotechnology. 2013, 31:20-3.

Ning L, Goossens E, Geens M, Van Saen D and Tournaye H (2012) Spermatogonial stem cells as a source for regenerative medicine. Middle East Fertility Society Journal, 17, 1-7.

Sui L, Mfopou JK, Geens M, Sermon K, Bouwens L. FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells. Biochemical and Biophysical Research Communications 2012, 426:380-385.

Mateizel I, Geens M, Van De Velde Hilde, Sermon Karen (2011) Establishment of hESC lines from the inner cell mass of blastocyst-stage embryos and single blastomeres of 4-cell stage embryos. Human Embryonic Stem Cells Handbook (K. Turksen, ed.); Methods in Molecular Biology. Springer

Geens M, Van de Velde H, Tournaye H (2011) Strategies for fertility preservation and restoration in the male. Facts, Views & Vision in ObGyn, 3, 302-310.

Geens M, Sermon K, Van de Velde H, Tournaye H (2011) Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells. Journal of Assisted Reproduction and Genetics, 28:471-480.

Geens M, Goossens E, Tournaye H. (2011) Cell selection by selective matrix adhesion is not sufficiently efficient for complete malignant cell depletion from contaminated human testicular cell suspensions. Fertility and Sterility, 95, 787-791.

Ning L, Goossens E, Geens M, Van Saen D, Van Riet I, He D, Tournaye H (2010) Mouse spermatogonial stem cells obtain morphologic and functional characteristics of hematopoietic cells in vivo. Human Reproduction, 25, 3101-3109.

Geens M, Mateizel I, Sermon K, De Rycke M, Spits C, Cauffman G, Devroey P, Tournaye H, Liebaers I, Van de Velde H (2009) Human embryonic stem cell lines derived from single blastomeres of two 4-cell stage embryos. Human Reproduction, 24, 2709-2717.

Spits C, Mateizel I, Geens M, Mertzanidou A, Staessen C, Vandeskelde Y, Van der Elst J, Liebaers I and Sermon K (2008) Recurrent chromosomal abnormalities in human embryonic stem cells. Nature Biotechnology, 26:1361-1363.

Goossens E, Geens M, Van Saen D, Ning L and Tournaye H (2008) Spermatogonial stem cells. An update on spermatogonial stem cell banking and transplantation. Internal Medecine, 15-16, 22-24.

Goossens E, Geens M, De Block G and Tournaye H (2008) Spermatogonial survival in long-term human pre-pubertal xenografts. Fertility and Sterility, 90:2019-2022.

Goossens E, Frederickx V, Geens M, De Block G, Tournaye H. (2008) Cryosurvival and spermatogenesis after allografting prepubertal mouse tissue: comparison of two cryopreservation protocols. Fertility and Sterility, 89,725-727.

Geens M, Goossens E, De Block G, Ning L, Van Saen D, Tournaye H. (2008) Autologous spermatogonial stem cell transplantation in man: current obstacles for a future clinical application. Human Reproduction Update, 14, 121-130.

Geens M, Van de Velde H, De Block G, Goossens E, Van Steirteghem A, Tournaye H. (2007) Isolation of germ cells from leukemic cells - Reply. Human Reproduction, 22, 2797-2798.

Geens M, Van de Velde H, De Block G, Goossens E, Van Steirteghem A, Tournaye H. (2007) The efficiency of magnetic-activated cell sorting and fluorescence-activated cell sorting in the decontamination of testicular cell suspensions in cancer patients. Human Reproduction, 22, 733-742.

Geens M, De Block G, Goossens E, Frederickx V, Van Steirteghem A, Tournaye H. (2006) Spermatogonial survival after grafting human testicular tissue to immunodeficient mice. Human Reproduction, 21, 390 - 396.

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